Upper Klamath Lake is a high desert lake in Southern Oregon of the United States some 4,100 feet (1,200 m) above sea level.
It is the largest body of fresh water by surface area in Oregon - approximately 25 miles (40 km) long and 8 miles (13 km) wide and extends northwest from the city of Klamath Falls.
In the last decade, a growing scientific interest has underlined the potentially huge role of adult stem cells in the maintenance and repair of human/animal life-sustaining tissues. Adult stem cells differ from embryonic stem cells as they are produced after birth; they are very similar to embryonic stem cells in their ability to differentiate into new and specialized cells. This process replaces dying or damaged cells, thus directly contributing to the regeneration of damaged bodily tissues.
Embryonic stem cells are totipotent, or able to differentiate into any cell of the body. Adult stem cells (ASC) can be multi-potent but also unipotent (able to self-renew into only one type of cell).
However, this is not necessarily a limitation. ASC are characterized as specific, compartmentalized cells. Some of them have many functions while others seem to have limited function.
So far, the list includes: hematopoietic, neural, mesenchymal, endothelial, mammary, olfactory, intestinal, and testicular stem cells. However, among the various types of ASC, only some seem to have the systemic ability to self-renew the organism:
Research shows that these types of stem cells constitute a system of self-maintenance and self-renewal able to keep the human/animal organism healthy and young.
The secret is to find natural substances, such as AFA microalgae, that are able to strongly support and maintain the activity and metabolism of those most fundamental stem cells.
AFA stands for Aphanizomenon flos-aquae, the “Invisible Flower of the Water.” There are about 60 different types of AFA. However, the one that is widely consumed as a nutritional supplement is the strain that is uniquely found in Upper Klamath Lake, Oregon, in the United States. It is specifically named Aphanizomenon flos-aquae Ralfs ex Born. & Flah. Var. flos-aquae.
Klamath AFA is unique due to the special conditions of the lake itself. Upper Klamath Lake is nested in an area of volcanic mountains with an altitude of about 1300 meters above sea level. Surrounded by desert, it experiences 300 days of sunshine per year which offers great opportunities for photosynthesis. The sunshine is followed by very cold winters whose freezing temperatures force AFA algae to produce essential fatty acids such as Omega 3.
The lake itself is rather large, measuring approximately 52 x 12 km, but also rather shallow, which favors microalgial photosynthesis. Ten meters of volcanic mineral deposits grants the unique mineral richness of Klamath AFA.
In spite of the negative remarks made by overzealous critics, the lake is as pristine as a lake can be today. It is one the most important sites for local and migrating birds in the Western United States. In the summer, one can find tens of thousands of birds as the sole inhabitants of the lake (of course, besides the vast stock of fish they feed upon). Species range from the famous Dancing Grebes to Pelicans to Bald Eagles—the symbol of the United States—which can only survive in unpolluted areas.
In this extraordinary environment, Klamath AFA is harvested in the wild and is possibly the richest food on Earth. In absolute terms, Klamath AFA beats pretty much any other food or superfood in terms of nutrition.
Its super-rich nutritional profile includes:
Klamath AFA also contains the largest array of more than 70 major minerals as well as trace minerals, including significant quantities of iron, natural fluorine, and vanadium, the latter of which is essential for insulin metabolism and the metabolic syndrome. Klamath AFA is also a good source of Omega 3 fatty acids and has the widest spectrum of carotenoids, including important xantophylls such as lutein, zaxanthin, astaxanthin and licopene. We also recently discovered that AFA has possibly the highest content of polyphenols of any living organism.
Speaking of nutraceutical molecules, Klamath AFA has such an important array of molecules that their discovery, over time, explained many of the apparently miraculous health effects that people reported experiencing.
It is from this research that specific AFA extracts were invented that concentrated some of the most relevant AFA molecules, mainly phenylethylamine (PEA) and supporting MAO-B inhibiting-enzyme molecules, to create a product with a wide scope of neuromodulating and immune-modulating properties; as well as AFA-phycocyanins, also concentrated in our extracts, with their antioxidant, anti-inflammatory, and anti-proliferative properties.
These molecules also work together to stimulate stem cell metabolism—an action that complements and completes the many essential properties we mentioned above—thus rendering the two complex extracts possibly the most perfect supplement to enhance health, wellness, and youthfulness.
Gennisi® is a proprietary combination of two patented AFA extracts which concentrate the relevant molecules from AFA 5-7:1. Each extract has independent and unique properties, but together they perform a complete action on both somatic and neuronal stem cells. Other AFA extracts were intended to concentrate similar molecules but attempts to copy our patented formula have failed.
Other AFA extracts were initially created to concentrate similar molecules even though competitors were probably secretly and illegally reproducing our patented formulations.
Today’s available extracts, however, are either fake, presented as extracts but really contain the same or less concentration than the whole algae, or they are diluted with other substances such as Spirulina. As such, their molecular concentration is lower than the whole AFA. Only with Gennisi® does one get the true extracts, endowed with many health-enhancing properties including the ability to work synergistically to promote both the release and the circulation of somatic and neuronal stem cells.
Warning! This is going to get very technical.
We have learned that stem cells are the regenerative mechanism our body uses to maintain our youth and health. Hematopoietic and mesenchymal stem cells are generated almost entirely in the marrow of different bones, while neural stem cells are generated within the brain through mechanisms that are still not fully understood.
In order for stem cells to be able to perform their reparative function, they must first be released from the original site of production and then migrate toward the bodily site in need of repair. The ways in which stems cells are released are various and still not fully known.
Hematopoietic stem cells are kept in the bone marrow. They are attached to cell receptors called Selectins (L-selectin, E-selectin). Substances that attach to the Selectin receptor prevent the attachment of the stem cells which are thus released into the bloodstream. AFA algae has been shown to contain one such L-selectin ligand which makes AFA able to stimulate the release of hematopoietic stem cells.
There are other mechanisms of release that are affected by AFA´s molecular components. A major one is the degradation of stem cell niches (where stem cells are kept in the body) by fibrinolysis (the dissolving of fibrin) and proteolysis (the dissolving of extra-cellular tissues by protease enzymes) which is something that AFA-phycocyanins do by stimulating both fibrinolysis and proteolysis directly, and by indirectly (via the stimulation of urokinase) activating the matrix metallo-proteinases, which are the endogenous molecules mainly responsible for the proteolytic degradation of unnecessary tissues. This is also the mechanism by which phycocyanins stimulate the proliferation and release of fibroblasts, the stem cells of the skin; but it also applies to almost all other mesenchymal stem cells, thus making AFA-phycocyanins a very powerful general somatic stem cell releaser.
One more path to enhance the release of stem cells has been recently discovered that is related to the circadian rhythms, insofar as they regulate the secretion of adrenaline into the bone marrow. Adrenaline enhances the proliferation of stem cells through various mechanisms.
Here, Gennisi® plays another important role as its PEA acts as an activator of the dopaminergic cascade, which leads to a higher production of adrenaline.
Finally, PEA extract has shown to play a very important role in the release and proliferation of neural stem cells—the brain and nervous system-specific stem cells. Our formula significantly increases in animals the production of brain erythropoietin (EPO), which is the general precursor of neuroblasts (the activated version of neural stem cells), which in turn is the mother of all neuronal tissues and neurotransmitters. Gennisi® thus promotes the release of stem cells, both somatic and neuronal, in almost all the various ways that have been identified as paths for their generation and release.
When we then move to the migration of stem cells, here too Gennisi® helps significantly. Once in the blood, stem cells have to migrate towards the bodily site in need of repair. Here emerges the cheating that has been done by other AFA companies and their presumed "scientists". They patented an AFA compound they defined as a polysaccharide to be concentrated through an ethanol extraction. However, soon after realizing that the actual mobilizing compound was a different one, they published an article explaining that the mobilizing factor for immune cells (which are very similar to stem cells) was a set of "low molecular weight peptides" without defining the actual nature of such compounds.
Among low molecular weight molecules are both PEA and mycosporine-like amino acids (MAAs), both of which are concentrated in the patented Gennisi® extract. Since companies could not reveal that they were actually reproducing our patented extract, other manufacturers kept talking about ethanol extract and polysaccharides. But the reality is that the molecules activating the migration of stem cells from the blood into tissues are PEA and MAAs, both of which have receptors in immune cells and very likely in stem cells, that migrate once PEA and MAAs attach to them. This means that Gennisi® and its components (AFA-phycocyanins, PEA, and MAAs) have the ability to act on all types of stem cells, both somatic and neuronal, stimulating both their release into the bloodstream and their migration from the bloodstream into organs and tissues.
This means that Gennisi®, which concentrates AFA-phycocyanins, PEA, and MAAs in its extracts, has the ability to act on all types of stem cells, both somatic and neuronal thus stimulating their release into the bloodstream and their migration from the bloodstream to organs and tissues.
While our AFA algae is harvested from Klamath Lake in Oregon, USA, the manufacturing branch of the Nutrigea group of companies, which is the group that owns the patents and has licensed Gennisi® to iGalen®, is in Italy. It is at the Blue Lotus Factory that the pre-mixed beverage formula has been developed. Very stringent quality controls guarantee that the product is clean, effective, and free of any contaminants or excipients.
Some benefits may be felt immediately, such as mental clarity and mood improvement. Other benefits emerge over time. Better energy, better sleep, and stress reduction may appear within the first few weeks. The same is true of sex drive and the reduction of nervous appetite. The effects on the immune system, either for winter illnesses or for allergies, can be seen within the first two to three months (in case of allergies, one should double the dose). For more therapeutic interventions involving neurodegenerative conditions, improvements can be seen surprisingly fast at times, but deeper results will require at least six months.
There are no known interactions with any pharmaceutical drug. Gennisi® has proven to reduce the side effects of chemotherapy without reducing the efficacy of treatment. As for food, the only interactions may be for the better, such as better digestion, better assimilation, and reduction of the glycemic index. However, for best results it would be best to drink Gennisi® on an empty stomach about 30 minutes before a meal.